PUBLICATIONS

Representative Publications

Recent publications from our lab in cancer genomics, targeted therapy, epigenetics, and antiviral research.

2026
ARTICLE

Protocol for the generation of DDT signaling reporter cell line for CRISPR screening

Zhengjin He, Shishuang Chen, Aowei Huang, Hai Jiang*

STAR Protocols 7(2):104523 2026
DOI: 10.1016/j.xpro.2026.104523
2025
ARTICLE

Genetic determinants of efficacy of antiviral drugs revealed by genome-wide CRISPR screens

Wei Jiang#, Ailing Yang#, Jingchuan Ma#, Dawei Lv, Mingxian Liu, Chao Wang, Shuo Chen, Huiling Fang, Yankai Chu, Zhengjin He, Wenrui Li, Yucheng Liu, Yun Zhao, Zhaocai Zhou, Gang Long*, Hai Jiang*

Antiviral Research 2025
DOI: 10.1016/j.antiviral.2025.106309
ARTICLE

STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency

Zhengjin He#, Shishuang Chen#, Jinlong Suo#, Kai Xia#, Mingxian Liu, Jingchuan Ma, Yankai Chu, Chao Wang, Yueru Xie, Wei Jiang, Hui Du, Shiyang Chen, Zhilei Zhou, Man Li, Qing Wei, Yun Zhao, Jianfeng Chen, Lin Li, Yi Zeng, Weiguo Zou, Moubin Lin*, Hai Jiang*

Cell Chemical Biology 2025
DOI: 10.1016/j.chembiol.2025.10.001
ARTICLE

A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2

Yankai Chu#, Shishuang Chen#, Mingyang Yang#, Yin Chen#, Huiling Fang#, Pinyu Huang, Yueru Xie, Chi Sun, Yun Chen, Baoding Zhang, Li Li, Hongchen Mu, Ding Song, Wentao Cheng, Chao Wang, Wei Jiang, Xiaolan Xu, Zhengjin He, Shuo Chen, Mingxian Liu, Jingchuan Ma, Man Yang, Jiaqi Cao, Jing Gao, Jiali Shen, Lulu Zhang, Yu Bai, Zheyi Liu, Jingyao Chen, Siqi Dai, Yi Arial Zeng, Yun Zhao, Hu Zhou, Chong Chen, Huanwei Ru, Li Tan, Ximin Chi, Fangjun Wang, Daming Gao, Moubin Lin, Xianming Deng*, Hai Jiang*

Nature Biotechnology 2025
DOI: 10.1038/s41587-025-02793-8
ARTICLE

Catalytic-independent functions of the Integrator–PP2A complex (INTAC) confer sensitivity to BET inhibition

Pengyu Fan#, Xue-Ying Shang#, Aixia Song#, Shuo Chen#, Run-Yuan Mao, Jingchuan Ma, Jiwei Chen, Zhenning Wang, Hai Zheng, Bolin Tao, Lei Hong, Jiaxian Liu, Wei Xu, Wei Jiang, Hongjie Shen, Qi Zhang, Huijuan Yang, Xiao-Ming Meng, Fei Lan, Jingdong Cheng, Congling Xu, Peng Zhang*, Hai Jiang*, Fei Xavier Chen*

Nature Chemical Biology 21(6):959-970 2025
DOI: 10.1038/s41589-024-01807-x
2024
REVIEW

Small-molecule drug screening and applications targeting RNA

Shuo Chen#, Man Yang#, Hai Jiang*

Chemistry of Life 44(9):1728-1736 2024
DOI: 10.13488/j.smhx.20240454
2023
ARTICLE

DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines

Ya-Hui Zhao#, Wei Jiang#, Hai Gao#, Guo-Zheng Pang, Yu-Shuang Wu, Yuan-Xian Wang, Meng-Yao Sheng, Jia-Ying Xie, Wan-Ling Wu, Zhi-Jian Ji, Ya-Rui Du, Lei Zhang, Xiao-Qin Wang, Colum P Walsh, Hai Jiang*, Guo-Liang Xu*, Dan Zhou*

Protein & Cell 14(7):532-537 2023
DOI: 10.1093/procel/pwac028
2021
REVIEW

Mutations and Copy Number Abnormalities of Hippo Pathway Components in Human Cancers

Zhengjin He, Ruihan Li, Hai Jiang*

Frontiers in Cell and Developmental Biology 9:661718 2021
DOI: 10.3389/fcell.2021.661718
ARTICLE

SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling

Liang Xu, Peixue Li, Xue Hao, Yi Lu, Mingxian Liu, Wenqian Song, Lin Shan, Jiao Yu, Hongyu Ding, Shishuang Chen, Ailing Yang, Yi Arial Zeng, Lei Zhang, Hai Jiang*

Protein & Cell 2021
DOI: 10.1007/s13238-020-00742-6
2020
ARTICLE

Defining relative mutational difficulty to understand cancer formation

Lin Shan#, Jiao Yu#, Zhengjin He, Shishuang Chen, Mingxian Liu, Hongyu Ding, Liang Xu, Jie Zhao, Ailing Yang, Hai Jiang*

Cell Discovery 6:48 2020
DOI: 10.1038/s41421-020-0177-8
2019
REVIEW

The expanding vulnerabilities of being UTXless

Hai Jiang*

Signal Transduction and Targeted Therapy 4:12 2019
DOI: 10.1038/s41392-019-0043-z
ARTICLE

Systematic analysis of drug vulnerabilities conferred by tumor suppressor loss

Hongyu Ding, Jie Zhao, Yanli Zhang, Jiao Yu, Mingxian Liu, Xiaoxi Li, Liang Xu, Minghui Lin, Chuan Liu, Zhengjin He, Shishuang Chen, Hai Jiang*

Cell Reports 27:3331-3344 2019
DOI: 10.1016/j.celrep.2019.05.043
2018
ARTICLE

UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma

Xiaoxi Li, Yanli Zhang, Liting Zheng, Mingxian Liu, Charlie Degui Chen, Hai Jiang*

Nature Communications 9(1):2720 2018
DOI: 10.1038/s41467-018-05084-w
2015
ARTICLE

A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency

Chuan Liu, Hongyu Ding, Xiaoxi Li, Christian P Pallasch, Liya Hong, Dianwu Guo, Yi Chen, Difei Wang, Wei Wang, Yajie Wang*, Michael T Hemann*, Hai Jiang*

EMBO Molecular Medicine 7(4):438-449 2015
DOI: 10.15252/emmm.201404580
ARTICLE

A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk

N Wang, H Ding, C Liu, X Li, L Wei, J Yu, M Liu, M Ying, W Gao, H Jiang*, Y Wang*

Oncogene 34(40):5198-5205 2015
DOI: 10.1038/onc.2014.443